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KMID : 0357920110450000062
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Korean Journal of Pathology
2011 Volume.45 No. 0 p.62 ~ p.65
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Bilateral Frontal Polymicrogyria - An Autopsy Case Report -
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Chun Yi-Kyeong
Choi Jong-Sun
Chi Je-G.
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Abstract
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Bilateral frontal polymicrogyria is a recently recognized syndrome characterized by symmetric polymicrogyria of both frontal lobes that presents with delayed motor and language development, spastic quadriparesis, and variable mental retardation. However, the postmortem findings of this syndrome are not fully elaborated. Here we describe an autopsy case of bilateral frontal polymicrogyria in a male fetus delivered at 22 weeks gestation due to extensive chorioamnionitis. The microscopic findings included a thinned cortical plate with fair neuronal maturation. There were no signs of neuronal damage and the white matter was unremarkable.
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KEYWORD
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Frontal lobe, Malformations of cortical development, Chorioamnionitis, Neuronal migration disorders
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